Increased expression of FGL2 in the explanted liver correlates with severity and recurrence of HCV infection. A: Chronic HCV patient with many FGL2-positive cells (brown cells) in the explant, who developed aggressive recurrent disease that did not respond to treatment. B: Chronic HCV patient who had only a few scattered FGL2-positive cells (brown cells) in the explant and has not required any treatment for recurrent HCV infection. Staining for FGL2 was performed by standard immunohistochemistry using a monoclonal anti-FGL2 antibody and the horse-radish immunoperoxidase method; magnification ×300.