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Figure 7.
A proposed model of FGL2 immunoregulatory activities. Treg production of FGL2 down-regulates adaptive immune responses through binding to the inhibitory FcγRIIB receptor, which is expressed on antigen-presenting cells. The suppressive activities of FGL2 result in inhibition of the immune response against the HCV, leading to viral persistence and chronic infection. DC, dendritic cells.