![An external file that holds a picture, illustration, etc., usually as some form of binary object. The name of referred object is rmmj_1-1-e0004f7.jpg](images\rmmj_1-1-e0004f7.jpg)
Figure 7.
A proposed model of FGL2 immunoregulatory activities. Treg production of FGL2 down-regulates adaptive immune responses through binding to the inhibitory FcγRIIB receptor, which is expressed on antigen-presenting cells. The suppressive activities of FGL2 result in inhibition of the immune response against the HCV, leading to viral persistence and chronic infection. DC, dendritic cells.