PubMed Central, : RMMJ Rambam Maimonides Medical Journal Rambam Health Care Campus 2010 July; 1(1): e0003. ISSN: 2076-9172Published online 2010 July 2. doi: 10.5041/RMMJ.10003.

Table 2.

Monoamine oxidase (MAO) subtypes, their substrates and inhibitors and cellular localization.

	MAO-A	MAO-B
Selective inhibitors (irreversible, covalent combination with enzyme active site)	Clorgyline	Selegiline (deprenyl), rasagiline
Selective inhibitors (reversible, competitive inhibition)	Moclobemide	Lazabemide
Non-selective inhibitors	Phenelzine, tranylcypromine
Selective substrates	5-HT, noradrenaline, adrenaline	β-phenylethylamine, benzylamine
Mixed substrates	Dopamine, tyramine
Cellular localization	Sympathetic neurons, noradrenergic, dopaminergic and other neurons in CNS, placenta, GI tract, hepatocytes and many other cell types	Astrocytes, platelets, many other peripheral cell types, serotonergic neuronal cell bodies in raphe nuclei

RMMJ Rambam Maimonides Medical Journal Rambam Health Care Campus 2010 July; 1(1): e0003. ISSN: 2076-9172

Published online 2010 July 2. doi: 10.5041/RMMJ.10003.