Figure 1.
Genomic structure of Hp alleles 1 and 2. Filled in boxes represent exonic sequences, dark lines represent intronic sequences. Hp 1 contains 5 exons. The Hp2 allele evolved from the Hp 1 allele following duplication of exons 3 and 4. Arrows pointing upward identify duplicated exons. Figure included with permission from Mary Ann Liebert, Inc. publishers (Levy et al, Antioxid Redox Signal 2010; 12:293–304).