Endothelial dysfunction (diabetes, hypertension, atherosclerosis, tobacco use).
Endothelial dysfunction (diabetes, hypertension, atherosclerosis, tobacco use).
Elevated asymmetric dimethyl arginine (ADMA) |
Elevated reactive oxygen species (ROS) |
Decreased NOS co-factors |
Decreased NOS activity |
Decreased NO production |
Increased peroxynitrite formation with increased removal of NO |
Possible role of L-arginine and anti-oxidant supplements |