Figure 5.
DADs and oscillatory prepotentials in CPVT iPSC cardiomyocytes induced by isoproterenol.
(A) Representative spontaneous recordings from control cardiomyocytes (30-day-old embryoid body (EB)), and (B,D) CPVT cardiomyocytes (32-, 30-, and 32-day-old EBs, respectively) in the absence (Tyrode’s) and presence of isoproterenol. Note that only in CPVT cardiomyocytes, isoproterenol caused DADs (red arrows) and negative chronotropic effect. Reprinted from Novak et al.37 with permission.