European Society of Cardiology (ESC) Unstable Angina/Non-ST-Elevation Myocardial Infarction (UA/NSTEMI) recommendations.
European Society of Cardiology (ESC) Unstable Angina/Non-ST-Elevation Myocardial Infarction (UA/NSTEMI) recommendations.
| Recommendation | Class | Level |
|---|---|---|
| Aspirin given at an initial loading dose of 150–300 mg and at a maintenance dose of 75–100 mg qd indefinitely | I | A |
| Ticagrelor (180-mg loading dose, 90 mg twice daily) for all pts at moderate-to-high risk of ischemic events regardless of initial treatment strategy and including those pretreated with clopidogrel (discontinued when ticagrelor is initiated) | I | B |
| Prasugrel (60-mg loading dose, 10-mg daily dose) is recommended for P2Y12 inhibitor-naïve pts in whom coronary anatomy is known and who are proceeding to PCI unless there is high risk of life-threatening bleeding | I | B |
| Clopidogrel (300-mg loading dose, 75-mg daily dose) for pts who cannot receive ticagrelor or prasugrel | I | A |
| A 600-mg loading dose of clopidogrel for pts scheduled for an invasive strategy when ticagrelor or prasugrel is not an option | I | B |
| A higher maintenance dose of clopidogrel 150 mg qd should be considered for the first 7 days in pts managed with PCI and without increased risk of bleeding | IIa | B |
| Increasing the maintenance dose of clopidogrel based on platelet function testing is not advised as routine, but may be considered in selected cases | IIa | B |
| Genotyping and/or platelet function testing may be considered in selected cases when clopidogrel is used | IIa | B |