PubMed Central, : RMMJ Rambam Maimonides Medical Journal Rambam Health Care Campus 2014 January; 5(1): e0005. ISSN: 2076-9172Published online 2014 January 21. doi: 10.5041/RMMJ.10139.

Table 3.

Staging, Chemotherapy Regimens, Response, and Latest Status.

All studied patients were contacted by the departmental secretary on January 1, 2012 and were found to be alive with no evidence of their previous testicular tumor. Remission was assessed and confirmed clinically, radiologically, and biochemically (B-HCG, LDH).

Pt. No. (Age at Diagnosis)	Side of Disease	Pathologic Staging of Testicular Seminoma	Stage	Regimen × No. of Cycles	Side Effects	Response
#1 (60)	Left	T2	IIC	BEP × 4	Neutropenic fever Mild peripheral neuropathy	CR
#2 (17)	Left	T1	IIC	BEP × 3	–	CR
#3 (39)	Right	T2	IIC ^a	BEP × 3	–	CR
#4 (47)	Left	T1	IIC ^b	BEP × 3; EP × 1	Bleomycin lung toxicity ^c Mild peripheral neuropathy	CR
#5 (55)	Left	T1	IIC ^d	BEP × 1; Carboplatin/etoposide/bleomycin × 2; Carboplatin/etoposide × 1		CR ^e
#6 (36)	Left	T1	IIC	BEP × 3	Bleomycin lung toxicity ^f	CR
#7 (42)	Right	T1	IIIA ^g	BEP × 3	Mucositis grade II	CR
#8 (43)	Right	T2	IIC	Carboplatin/bleomycin/etoposide × 4		CR
#9 (41)	Right	T1	IIC	EP × 3	Neutropenic fever	CR
#10 (33)	Left	T1	IIC	BEP × 3		CR
#11 (50)	Left	T1	IIC	CDDP/VP-16 × 4	Neutropenic fever	CR
#12 (53)	Bilateral	T1	IIC	BEP × 4	Mild hearing loss	CR
#13 (23)	Right	T1	IIB	BEP × 3; EP × 1		CR
#14 (66)	Right	T1	IIIA	BEP × 3; EP × 1		CR
#15 (32)	Right	T2 ^h	IIC	BEP × 3; EP × 1		CR
#16 (46)	Right	T2	IIC ⁱ	BEP × 3	Mucositis grade III	CR
#17 (42)	Right	T1	IIB	BEP × 3	Mild tinnitus	CR
#18 (27)	Left	T1	IIIB	BEP × 3		CR
#19 (29)	Right	T1 ^h	IIC	BEP × 3		CR ^j
#20 (34)	Left	T2 ^j	IIB	BEP × 3	Bleomycin lung toxicity ^k	CR
#21 (32)	Right	T1	IIB	BEP × 3		CR
#22 (21)	Right	T1	IIC	BEP × 4		CR ^l
#23 (31)	Right	T1	IIB	BEP × 3	Herpes zoster	CR ^m
#24 (43)	Left	T1	IIC	BEP × 3		CR ⁿ
#25 (51)	Left	T1	IIIA ^o	BEP × 3		CR
#26 (33)	Right	T1	IIB	BEP × 4	Neutropenic fever	CR

^aPatient #3 presented with very advanced retroperitoneal mass, measuring 10 × 9 × 13 cm; unilateral hydronephrosis; involved right-sided ureter.

^bPatient #4 presented with massive retroperitoneal and pelvic lymphadenopathy, hydronephrosis and hydroureter.

^cBleomycin lung toxicity (BIP) = clinically asymptomatic, radiological diagnosis; cumulative bleomycin dose 180 units.

^dRetroperitoneal lymphadenopathy, measuring 9.5 × 13.5 × 7.5 cm; left-sided hydronephrosis; involved diaphragmatic crus.

^eSlow radiological response—it took several months until complete resolution of residual mass.

^fClinically asymptomatic, radiological manifestation; reaching total bleomycin dose 240 units.

^gIIIA = retroperitoneal, mediastinal, and left-sided supraclavicular groove lymphadenopathy; pathologically confirmed.

^hSeminoma with intratubular germ cell tumor.

ⁱHuge retroperitoneal mass, obstructed left kidney with resulting hydronephrosis, necrotic mass in the midline, inguinal and external iliac lymphadenopathy.

^jPatient preferred surveillance initially; relapsed 9 months later with abdominal pain and retroperitoneal mass (52 mm); in complete remission.

^kVery symptomatic with radiological signs; treated successfully with high-dose steroids; cumulative bleomycin dose 240 units.

^lPatient relapsed with lung metastasis 1 year following BEP; responded to second-line chemotherapy with ifosfamide-based chemotherapy for 4 years; disease recurred in lungs and pelvis; entered third CR following HDCT with APSCT and local radiation therapy; alive NED for 168 months.

^mPET-CT-confirmed CR.

ⁿGallium scan-proven CR.

^oBiopsy-proven metastatic lymphadenopathy in the left supraclavicular groove.

CR, complete response; EP, etoposide/cisplatinum.