Clinical and Pathological Comparison of Spermatocytic Variant of Classic Seminoma (SVCS) with Classic Seminoma (CS).
Clinical and Pathological Comparison of Spermatocytic Variant of Classic Seminoma (SVCS) with Classic Seminoma (CS).
| Spermatocytic Seminoma | Classic Seminoma | |
|---|---|---|
| CLINICAL | ||
| 1. Site of origin | Testis only | Testis, ovary, retroperitoneum, central nervous system (midline structures) |
| 2. Arise in cryptorchid testes | No | 10% |
| 3. Age (years): mean (range) | 54 (25–87) | 41 (childhood to 85+) |
| 4. Fraction of testis involved by tumor | 2% | 40% |
| 5. Associated other germ cell tumor types | None | Common |
| 6. Association with sarcoma of testis | 5% | None |
| MICROSCOPIC PATHOLOGY | ||
| 1. Cell size | Small, medium, large | Medium |
| 2. Nuclei | Spherical | Irregular |
| 3. Cytoplasm | Eosinophilic to amphophilic | Pale to clear |
| 4. Cytoplasmic glycogen | Absent | Abundant |
| 5. Edema fluid | Often present | Absent |
| 6. Lymphocytic infiltrate | Sparse to absent | Prominent |
| 7. Syncytiotrophoblast | None | Occasional |
| 8. Granulomas | None | Occasional |
| 9. Lymphocyte-rich fibrovascular septae | Absent | Present |
| 10. Associates intratubular germ cell tumor | None | Common |
| 11. Microcystic pseudoglandular formation | Present | Absent |
| MOLECULAR BIOLOGY/IMMUNOHISTOCHEMISTRY | ||
| 1. Placental alkaline phosphatase staining | Rarely | Strong, diffuse |
| 2. CD-117 staining | Absent | Present |
| 3. Cytokeratin 18 | Absent | Present |
| 4. S-phase fraction | Twice as great as classic seminoma | |
| 5. DNA content | <3N | >3N |
| 6. Gene overexpression chromosome 9 | Positive | Negative |