Conditioning Regimen Intensity.

The more intense and myeloablative the protocol, the more toxic it is and less in need to rely on graft-versus-leukemia (GVL) for residual disease elimination. Reduced-intensity regimens are less toxic and rely more on an immunotherapeutic GVL effect to prevent relapse. Conditioning may include also the use of anti-thymocytic globulins in MUD HSCT. HSCT, hematopoietic stem cell transplantation; MUD, matched unrelated donor; TBI, total body irradiation. * The number represents the radiation dose in Rads. †New conditioning in phase II trial for chronic lymphocytic leukemia patients.²⁴