Models and Mechanisms of Pro- and Anti-fibrotic Effects of γδ T Cells.
Models and Mechanisms of Pro- and Anti-fibrotic Effects of γδ T Cells.
| Model | Pro-fibrotic | Anti-fibrotic | Mechanism | Ref |
|---|---|---|---|---|
| BLM-induced murine lung fibrosis | + | IL-17 production by γδ T and TH17 cells | 25 | |
| BLM-induced murine lung fibrosis | + | Production of CXCL10 by γδ T cells | 29 | |
| BLM-induced murine lung fibrosis | + | IL-22 produced by γδ T cells | 30 | |
| BLM-induced lung fibrosis in osteopontin-deficient mice | + | IFN-γ-producing γδ T cells | 31 | |
| Melphalan-induced murine lung fibrosis | + | Induction of pro-inflammatory cytokines, e.g. IL-6 and IL-1β | 34 | |
| Bacillus subtilis-induced murine lung fibrosis | + | IL-17A-expressing γδ T cells involvement in removal of offending organism | 35 | |
| Bacillus subtilis-induced murine lung fibrosis | + | Production of IL-22 by γδ T cells | 36 | |
| Bacillus subtilis-induced murine lung fibrosis | + | Immunoregulatory role of Vγ6/Vδ1(+) γδ T cell subset | 35 | |
| Carbon tetrachloride (CCl4) murine model of liver fibrosis | + | TLR3 activation of IL-17 secretion by γδ T cells | 39 | |
| Carbon tetrachloride (CCl4) murine model of liver fibrosis | + | Promotion of apoptosis of hepatic stellate cells by γδ T cells | 40 | |
| Cryptosporidium parvum infection-induced murine liver periportal fibrosis | + | No mechanism presented | 42 | |
| Rotavirus infection inducing murine biliary atresia | + | IL-17 production by γδ T cells | 43 | |
| Schistosoma japonicum-induced murine liver fibrosis | + | IL-17 production by γδ T cells | 44 | |
| In vitro experiments using human cells | + | Cell contact-dependent apoptosis of fibroblasts and reduction of collagen secretion byproducts of Vγ9Vδ2+T cells | 18, 19 | |
| In vitro human experiments | + | Increased fibroblast proliferation and collagen production by supernatants of γδ T cells of systemic sclerosis patients | 20, 21 |