Figure 8.
NAC Decreases Fetal Injury as Demonstrated by MRI Following Maternal Inflammation.
T2 voxel-based t test analysis, comparing the LPS-treated and the LPS-NAC groups, both with neonatal brain MRI at day 25 after delivery.
(A) Images of T2 MRI comparing the LPS group and the LPS-NAC group (higher T2 implies brain damage). The colored areas indicate significant differences in T2 between the LPS group and the LPS-NAC group. The significant regions are superimposed on T2 relaxation maps (P<0.001).
(B) The graphs present averaged T2 values at significant brain regions in the LPS group, the LPS-NAC group, and the control group. The LPS group included SAL-LPS-SAL; the LPS-NAC group included NAC-LPS-NAC; the control included SAL-SAL-SAL. *P<0.05. LPS, lipopolysaccharide; MRI, magnetic resonance imaging; NAC, N-acetyl cysteine; SAL, saline. Reprinted from Beloosesky et al.,17 Copyright (2013), with permission from Elsevier.