Staging ⁶⁸Ga PSMA PET/CT scan in a 59-year old male with newly diagnosed prostate cancer (Gleason score, 7) demonstrates pathological PSMA uptake involving most of the left prostate lobe and extending across the midline (A), a right pelvic lymph node metastasis (B), and a left iliac bone metastasis (arrows) (C). PSMA PET is sensitive for detection of micrometastases in nodes less than 1 cm in short axis measurement, as in (C). Additional sites of lymphadenopathy and skeletal metastases were demonstrated on this PSMA PET/CT study (not shown).