Cannabis/Cannabinoids Administration for Graft versus Host Disease (GVHD) Prophylaxis.

A: Recipient BALB/c mice (R) received lethal whole-body irradiation and were reconstituted with 8×10⁶ donor C57BL/6 (D) bone marrow cells and 2×10⁶ spleen cells. Cannabis/cannabinoids were administered IP every other day, for 2 weeks from the day of transplantation. The clinical condition of the mice was evaluated for up to 67 days after transplantation. B: Survival curve THC and CBD, pure cannabinoids treated groups; THC BDS and CBD BDS, cannabis extracts treated groups. C: Average GVHD score THC and CBD, pure cannabinoids treated groups; THC BDS and CBD BDS, cannabis extracts treated groups. Modified from Figure 6 in Khuja et al.¹⁷; reused under creative commons license (CC BY 4.0).

BDS, botanical drug substance; CBD, cannabidiol; IP, intraperitoneally; TCH, Δ9-tetrahydrocannabinol.