Figure 4. Genetic Variation Affects Major Adverse Clinical Events (MACE) and Survival in Response to Delivery of MSCs
POSEIDON-DCM patients negative for pathologic genetic variants (V−, green) had fewer MACE (A) and greater survival (B) than patients with variants of uncertain significance (VUS, orange) or pathologic/likely pathologic variants (PV+, red). Overall, PV+ patients had a substantial increase in death, transplant, or left ventricular assist device (LVAD) risk by 1-year follow-up. From Figure 3, Rieger et al.96 [CC BY-NC-ND 4.0].