PubMed Central, : RMMJ Rambam Maimonides Medical Journal Rambam Health Care Campus 2020 April; 11(2): e0015. ISSN: 2076-9172Published online 2020 April 29. doi: 10.5041/RMMJ.10401.

Table 1.

Comparison of Cell Types.

Cell Type	Preclinical Animal Studies (n)		Completed Clinical Studies at ClinicalTrials.gov (n)			Change in Clinical Data
	Preclinical Animal Studies (n)		Completed Clinical Studies at ClinicalTrials.gov (n)			LVEF (%)			EDV (mL)			Change in Scar Size (%)
	AMI	ICM	AMI	ICM	NIDCM	AMI	ICM	NIDCM	AMI	ICM	NIDCM	AMI	ICM
MSCs	335	133	4^*	6^†	2^‡	6.0	5.7	8.0	N/A	−9.3	N/A	−6.2	−25.9
CPCs	182	87	0	1^§	0	N/A	5.4	N/A	N/A	−12	N/A	N/A	−12
ESCs	3	0	0	1^**	0	N/A	12.5	N/A	N/A	−14.5	N/A	N/A	N/A
iPSCs	3	0	0	0	0	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A

^*References ⁶⁵^,⁶⁶^,¹¹², and ¹¹³.

^†References ⁷¹^–⁷⁴^,⁷⁵^,¹¹⁴, and ¹¹⁵.

^‡References ²⁵ and ⁹⁸

^§Reference ¹¹⁶.

^**Reference ⁴¹. Cells delivered via patch not intramyocardial.

Initial search criteria: Heart or cardiac, cells, completed studies, with results (=148 results on clinicaltrials.gov). An advanced search of these results was performed for “acute myocardial infarction,” “ischemic cardiomyopathy,” or “non-ischemic dilated cardiomyopathy,” each with the intervention of: “mesenchymal stem cells” for MSCs; “cardiosphere-derived stem cells” and “cardiopoietic stem cells” for CPCs; “embryonic stem cells” for ESCs; or “induced pluripotent stem cells” for iPSCs.

N/A, data not available.

RMMJ Rambam Maimonides Medical Journal Rambam Health Care Campus 2020 April; 11(2): e0015. ISSN: 2076-9172

Published online 2020 April 29. doi: 10.5041/RMMJ.10401