Case Reports of Myoclonus Secondary to Acetylcholinesterase Inhibitors.
Case Reports of Myoclonus Secondary to Acetylcholinesterase Inhibitors.
| Reference | Drug | Age/Sex | Comorbidities | Clinical Manifestations | Management | Follow-up |
|---|---|---|---|---|---|---|
| Colebatch and Bacsi (2007)2 | Galantamine | 69/F | Dementia, mitral valve prolapse, atrial fibrillation, depression, macular degeneration, benign colonic polyps, transient ischemic attack | Multifocal myoclonus affecting upper and lower limbs | NA | NA |
| Hernández-Fernández et al. (2011)3 | Galantamine | 80/M | Alzheimer’s disease, hypertension, dyslipidemia, and chronic renal failure | Respiratory myoclonus, also known as diaphragmatic flutter | Galantamine was discontinued; valproic acid and clonazepam were started | After 3 weeks, he was asymptomatic |
| Luna (2012)4 | Galantamine, 4 months | 87/M | Dementia | Multifocal myoclonus | Galantamine was discontinued | Movement symptoms resolved 2 weeks later |
| Bougea et al. (2014)5 | Donepezil, 25 days | 80/F | Alzheimer’s disease | Myoclonus in both upper and lower extremities | Donepezil was discontinued | Myoclonus resolved within 36 hours |
| Whateley et al. (2018)6 | Donepezil, 7 weeks | 93/F | Alzheimer’s disease, hypertension | Multifocal myoclonic non-synchronous, affecting all four limbs at rest | Donepezil was discontinued | Myoclonus resolved within 2 days |
| Amlang et al. (2019)7 | Donepezil, 4 weeks | 67/M | Occipital strokes, hypertension, diabetes mellitus type 1, hepatitis C | Multifocal myoclonic movements of head, face, upper extremities, and trunk | Donepezil was discontinued; clonazepam was started | Myoclonic movements subsided within 1 day |
| Present case (2023) | Donepezil, 4 weeks | 61/F | Mild cognitive impairment, hypertension | Multifocal myoclonus of distal limbs and face; myoclonus worsened with action | Donepezil was discontinued; clonazepam was started | Myoclonus subsided within 1 day |