Randomized Controlled Trials Comparing Outcomes of Endoscopic Sphincterotomy (ES) Laparoscopic Common Duct Exploration (Lap.), and Laparo-Endoscopic Rendezvous Technique (Lap.-ES), 2001–2010.
Randomized Controlled Trials Comparing Outcomes of Endoscopic Sphincterotomy (ES) Laparoscopic Common Duct Exploration (Lap.), and Laparo-Endoscopic Rendezvous Technique (Lap.-ES), 2001–2010.
| Author | Intervention | Mean Age y (range or SD) | Pts. n | Stone Clearance n (%)* | Additional CBDI needed (ES or Surg.) n (%)† | Minor and Major Complications n (%)† | Mortality n (%) | Length of Hospital Stay d (mean or mean range) | Author Conclusions |
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| Sgourakis and Karaliotas (2002)46 | ES | 46–89 | 42 | 27/32 (84.3) | 5/42 (11.9) | 6/42 (14.3) | 1/42 (2.4) | 9.0 | There is a need for further randomized trials |
| Lap. | 43–88 | 36 | 24/28 (85.7) | 4/36 (11.1) | 5/36 (13.9) | 1/36 (2.8) | 7.4 | ||
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| Hong et al. (2006)47 | ES | Not given | 93 | 85/93 (91.4) | 8/93 (8.6) | 9/93 (9.4) | 0 (0.0) | 4.3 | ES and Lap. are safe and effective treatments for CBD stones |
| Lap. | 48 (15–82) | 141 | 126/141 (89.4) | 15/141 (10.6) | 8/141 (5.6) | 0 (0.0) | 4.7 | ||
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| Lella et al. (2006)52 | ES | Not given (<60) | 60 | 58/60 (96.7) | 0/60 (0.0) | 8/60 (13.3) | 0 (0.0) | 6 | Lap.-ES prevents post-ES pancreatitis in patients at risk for this complication |
| Lap.-ES | Not given (<60) | 60 | 59/60 (98.3) | 2/60 (3.3) | 2/60 (3.3) | 0 (0.0) | 3 | ||
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| Morino et al. (2006)4 | ES | 63.1 (25–83) | 45 | 9/45 (80.0) | 17/45 (37.8) | 3/45 (6.6) | 0 (0.0) | 8.0 | Lap.-ES carries a higher rate of CBD stones clearance and shorter hospital stays than ES |
| Lap.-ES | 56.6 (22–82) | 46 | 44/46 (95.6) | 3/46 (6.5) | 3/46 (6.5) | 0 (0.0) | 4.3 | ||
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| Rábago et al. (2006)51 | ES | Not given (<80) | 64 | 28/31 (90.5) | 7/64 (10.9) | 12/64 (18.8) | 0 (0.0) | 8 | Lap.-ES had less morbidity and a shorter hospital stay than ES |
| Lap.-ES | Not given (<80) | 59 | 20/25 (80.0) | 4/59 (6.8) | 3/59 (5.1) | 0 (0.0) | 5 | ||
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| Noble et al. (2009)48 | ES | 74.3 (70–79) | 47 | 26/46 (56.5) | 2/47 (4.3) | 8/47 (17.0) | 0 (0.0) | 3 | No difference in hospital stay, complications, or conversion. Lap. was more effective and avoided unnecessary procedures |
| Lap. | 75.9 (70–81) | 44 | 38/38 (100) | 4/44 (9.1) | 8/44 (18.2) | 0 (0.0) | 5 | ||
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| Bansal et al. (2010)50 | ES | 39.1 (23–64) | 15 | 11/15 (73.3) | 2/15 (13.3) | 4/15 (26.7) | 0 (0.0) | 4.0 | Equivalent morbidity and hospital stay. Lap. carried a smaller number of procedures |
| Lap. | 47.1 (34–72) | 15 | 14/15 (93.3) | 1/15 (6.7) | 4/15 (26.7) | 0 (0.0) | 4.2 | ||
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| Rogers et al. (2010)49 | ES | 44.6±1.9 | 55 | 30/31 (98) | 1/55 (1.8) | 5/55 (9.1) | 0 (0.0) | 6.6 | ES and Lap. are highly effective in treating CBD stones. Hospital stay was shorter for Lap. |
| Lap. | 39.9±1.9 | 57 | 15/17 (88) | 2/57 (3.5) | 6/57 (10.5) | 0 (0.0) | 5.3 | ||
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| Total | ES | 421 | 274/353 (77.6) | 42/421 (9.8) | 55/421 (13/1) | 1/421 (0.2) | 3–9 | ||
| Lap. | 293 | 217/239 (90.8) | 26/293 (8.9) | 31/293 (10.6) | 1/293 (0.3) | 4.2–7.4 | |||
| Lap.-ES | 165 | 123/131 (93.9) | 9/165 (5.5) | 8/165 (4.8) | 0/165 (0.0) | 3–5 | |||