Randomized Controlled Trials Comparing Outcomes of Endoscopic Sphincterotomy (ES), Laparoscopic Common Duct Exploration (Lap.), and Laparo-Endoscopic Rendezvous Technique (Lap.-ES), 2011–2023.
Randomized Controlled Trials Comparing Outcomes of Endoscopic Sphincterotomy (ES), Laparoscopic Common Duct Exploration (Lap.), and Laparo-Endoscopic Rendezvous Technique (Lap.-ES), 2011–2023.
| Author | Intervention | Mean Age y (range or SD) | Patients n | Stone Clearance n (%)* | Additional CBDI Needed (ES or Surg.) n (%)† | Complications n (%)† | Mortality n (%) | Length of Hospital Stay d (mean or mean range) | Author Conclusions |
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| ElGeidie et al. (2011)53 | ES | 29.2 (20–67) | 111 | 98/107 (91.6) | 7/111 (6.3) | 10/111 (9.3) | 0 (0.0) | 3.1 | ES and Lap. safe and effective treatments for CBD stones |
| Lap. | 32.5 (19–64) | 115 | 104/110 (94.5) | 9/115 (7.8) | 8/115 (7.0) | 0 (0.0) | 2.2 | ||
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| Ferulano et al. (2011)54 | ES | 55±15 | 62 | 37/39 (95) | Not given | 6/62 (9.7) | 0 (0.0) | 3.5 | Lap. avoids cholangitis, papillary stenosis, or pancreatitis after ES |
| Lap. | 53±13 | 62 | 42/45 (93) | Not given | 4/62 (6.5) | 0 (0.0) | 7.1 | ||
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| Tzovaras et al. (2012)59 | ES | 69 (25–85) | 49 | 39/49 (79.6) | 1/49 (2.0) | 6/49 (12.2) | 0 (0.0) | 5.5 | Lap.-ES carries less hospital stay and lower amylase levels than ES |
| Lap.-ES | 66 (22–87) | 50 | 44/50 (88.0) | 2/50 (4.0) | 7/50 (14) | 1/50 (2.0) | 4 | ||
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| Koc et al. (2013)55 | ES | 54.9±17.9 | 54 | 51/54 (94.4) | 1/54 (1.9) | 6/54 (11.1) | 0 (0.0) | 6 | Lap. has less morbidity and allows earlier recovery than ES |
| Lap. | 51.5±16.6 | 57 | 55/57 (96.5) | 0/57 (0.0) | 4/57 (7.0) | 0 (0.0) | 3 | ||
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| Bansal et al. (2014)56 | ES | 45.1±15.1 | 84 | 73/83 (88.0) | 16/84 (19.1) | 19/84 (22.6) | 3/84 (3.7) | 5.3 | Lap. has shorter hospital stays and needs fewer procedures |
| Lap. | 43.0±13.7 | 84 | 77/84 (91.7) | 10/84 (11.9) | 20/84 (23.8) | 0 (0.0) | 4.6 | ||
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| Ding et al. (2014)57 | ES | 57.5±6.3 | 111 | 105/111 (94.6) | 1/111 (0.9) | 6/111 (5.4) | 0 (0.0) | NG | Lap. is the treatment of choice for patients with CBD stones |
| Lap. | 58.4±7.2 | 110 | 103/110 (93.6) | 3/110 (2.7) | 4/110 (3.6) | 0 (0.0) | NG | ||
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| Sahoo et al. (2014)60 | ES | 48 (21–75) | 41 | 29/41 (70.7) | NG | NG | 0 (0.0) | 10.9 | Lap.-ES reduces pancreatitis, hospital stays, and interventions |
| Lap.-ES | 48 (21–75) | 42 | 38/42 (90.5) | NG | NG | 0 (0.0) | 6.8 | ||
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| Barreras González et al. (2016)61 | ES | 57.7 (20–84) | 101 | 42/45 (93.3) | Not given | 6/101 (5.9) | 0 (0.0) | 3.1 | Lap.-ES shows a higher rate of CBD stone clearance, a shorter hospital stay, and lower morbidity |
| Lap. | 56.3 (22–87) | 100 | 42/43 (97.7) | Not given | 2/100 (2.0) | 0 (0.0) | 2.1 | ||
| Lap.-ES | 58.4 (23–87) | 99 | 45/46 (97.8) | Not given | 0/99 (0.0) | 0 (0.0) | 1.2 | ||
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| Lv et al. (2016)58 | ES | 63.5±12.4 | 24 | 22/24 (91.7) | 2/24 (8.3) | 3/24 (12.5) | 0 (0.0) | 10.9 | Lap.-ES resulted in a shorter hospital stay |
| Lap.-ES | 61.3±14.5 | 29 | 28/29 (96.6) | 1/29 (3.4) | 1/29 (3.4) | 0 (0.0) | 6.7 | ||
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| Total | ES | 637 | 496/553 (89.7) | 28/433 (6.5) | 62/596 (10.4) | 3/637 (0.5) | 3.1–10.9 | ||
| Lap. | 528 | 423/449 (94.2) | 22/366 (6.0) | 42/528 (8.0) | 0/528 (0.0) | 2.1–7.1 | |||
| Lap.-ES | 220 | 155/167 (92.8) | 3/79 (3.8) | 8/178 (4.5) | 1/220 (0.5) | 1.2–6.8 | |||