PubMed Central, : RMMJ Rambam Maimonides Medical Journal Rambam Health Care Campus 2024 October; 15(4): e0017. ISSN: 2076-9172Published online 2024 October 28. doi: 10.5041/RMMJ.10531

Table 2.

PICOS Strategies.

Criteria	Definitions
Population	Damaged corneal endothelial animal model
Intervention	MSCs
Comparator	Any comparator
Primary outcomes	Between-group level differences of TGF-β, and IL-1, endothelial cell count and corneal thickness
Secondary outcomes	Between-group level differences of FGF, endothelial cell count, and corneal thickness
Study design	Original animal experimental studies

FGF, fibroblast growth factor; IL-1, interleukin-1; MSCs, mesenchymal stem cells; PICOS, population, intervention, comparison, outcome, studies; TGF-β, transforming growth factor beta.

RMMJ Rambam Maimonides Medical Journal Rambam Health Care Campus 2024 October; 15(4): e0017. ISSN: 2076-9172

Published online 2024 October 28. doi: 10.5041/RMMJ.10531