Study Outcomes.
Study Outcomes.
| Author (Year) | Assessed Outcome | Main Result |
|---|---|---|
| Ali et al. (2021)13 | Efficacy of cryopreserved human embryonic stem cell-derived CECs to form a functional monolayer of corneal endothelium | CEC density of injected eye was >80% of the CEC density of the untreated eye
Central corneal thickness of the injected eye remained comparable (±20 mm) to the untreated eye |
| Alio del Barrio et al. (2015)14 | Biocompatibility of grafts composed of sheets of decellularized human corneal stroma with or without the recellularization of human adipose-derived adult stem cells into the rabbit cornea | The hypocellular band was observed, containing cells with stellate morphology around and inside the sheet in the treated group |
| Damala et al. (2023)15 | Effectiveness in stopping corneal scar development and corneal surface regeneration | In every treatment arm, the damaged corneal surface area progressively shrank |
| Demirayak et al. (2016)16 | Corneal scarring after penetrating injury | Significant difference in the mean anterior keratocyte density and mean posterior keratocyte density values of the transplanted groups versus the control group |
| Di et al. (2017)17 | Diabetic corneal epithelial wound healing | Defect area of corneal epithelium in MSC-treated diabetic mice significantly improved compared to untreated diabetic mice |
| Nieto-Nicolau et al. (2021)18 | Human AT-MSCs for corneal surface regeneration | AT-MSCs cultured with standard medium improved corneal transparency and decreased neovascularization in comparison with non-treated and amniotic membrane-treated groups |
| Ryu et al. (2023)19 | Corneal endothelial cells proliferation | Exosomes generated from AT-MSCs facilitated endothelial cell regeneration and wound healing by causing a change in the cell cycle and inhibiting autophagy and senescence |
| Saccu et al. (2022)20 | Corneal repair through histological and molecular analyses | Bone marrow-derived-MSC-derived extracellular vesicle formulation significantly accelerated corneal repair by modulating cell death, inflammation, and angiogenesis in a murine model of alkali-burn-induced corneal damage; similar effects observed in vitro on human corneal epithelial cells |
| Sendon-Lago et al. (2019)21 | The effect and mechanism of action of the CM-hUCESC on corneal wound healing | CM-hUCESC induces faster corneal regeneration in a rabbit atropin-induced dry eye model and reduces corneal pro-inflammatory cytokines |
| Shukla et al. (2019)22 | The efficacy of MSC administration in corneal injury | MSCs significantly suppressed injury-induced corneal opacification |
| Sun et al. (2017)23 | The expansion and function of HCECs | High expression levels of vimentin, CD29, CD105, CD49e, and CD166 noted in cultured human OASCs
Expression of CEC-related markers zonula occludens-1 (ZO-1), Na+/K+ ATPase, N-cadherin, Col8a2, and SLC4A4 in OASC-CM-cultivated HCECs The HCECs maintained their excellent proliferative ability and polygonal cell shape Corneal transparency achieved in animals after HCEC-injection |
| Then et al. (2017)24 | The effectiveness of treating corneal stromal deficiency using autologous MSCs generated from bone marrow | Localization of PKH26-labeled BM-MSCs revealed increased cell density in the transplanted location, indicating a role in corneal stromal regeneration |
| Ye et al. (2022)25 | The efficacy of anterior chamber injection of MSC-induced CECs | Human umbilical cord-derived MSCs were successfully differentiated into CECs in vitro; injection into a rabbit model of CED improved corneal opacity and neovascularization |
AT-MSCs, adipose tissue-derived mesenchymal stem cells; BM-MSCs, bone marrow mesenchymal stem cells; CEC(s), corneal endothelial cell(s); CED, corneal endothelial dysfunction; CM-hUCESC, conditioned medium from human uterine cervical stem cells; HCECs, human corneal endothelial cells; MSC(s), mesenchymal stem cell(s); OASCs, orbital adipose-derived stem cells; OASC-CM, orbital adipose-derived stem cells conditioned medium.