Table 1.

Overview of Tools Used in Diagnosing and Treating Cognitive Impairment.

Tool Purpose
Neuropsychological Test Tools
Mini-Mental State Examination (MMSE)32 Used for initial cognitive screening, assessing orientation, memory, attention, and language
Montreal Cognitive Assessment (MoCA)13,33 Designed for detecting mild cognitive impairment (MCI), assessing a broad range of cognitive functions
MoCA-CFS Composite Score34 Used to evaluate hepatic encephalopathy severity and predict health deterioration
Wechsler Adult Intelligence Scale (WAIS)35 Provides insights into various cognitive functions like memory, executive function, and processing speed
Cambridge Neuropsychological Test Automated Battery (CANTAB)36 Provides detailed insights into cognitive functions such as memory, executive function, and processing speed
Neuropsychological Assessment Battery (NAB)37 A comprehensive set of subtests assessing cognitive domains like attention, memory, and executive function
Psychiatric Questionnaires
Beck Depression Inventory (BDI)38 Assesses depression severity, including somatic and cognitive-affective symptoms
Hospital Anxiety and Depression Scale (HADS)39 Designed to measure anxiety and depression in patients with somatic conditions
Fatigue Severity Scale (FSS)40 Assesses fatigue severity, useful in conditions like hepatitis C and multiple sclerosis
Neuroimaging Techniques
Magnetic Resonance Imaging (MRI)41 Assesses structural brain changes (atrophy, lesions, white matter abnormalities) to differentiate dementia types
Positron Emission Tomography (PET)42 Measures brain activity and glucose metabolism, aiding in diagnosing Alzheimer’s and neurodegenerative diseases
Functional MRI (fMRI)43 Assesses brain activity and connectivity, useful for studying cognitive processes in research
Cognitive Impairment Assessment
Electronic Montreal Cognitive Assessment (eMoCA)44 Digital version of MoCA for portable cognitive assessment
Digital Clock Drawing Test (dCDT)44 Digital version of the Clock Drawing Test, used for assessing cognitive domains
Geras Solutions Cognitive Test (GSCT)43 A computerized test designed for screening and assessing cognitive functions
CogState47 A cognitive assessment using computerized tasks designed for detailed cognitive evaluation
Computerized Cognitive Screen (CoCoSc)43 Used for screening cognitive impairments and evaluating cognitive performance via computerized tasks
Virtual Reality-based Cognitive Tools45 Utilizes virtual reality and spatial navigation to assess cognitive function through interactive environments
Artificial Intelligence-based Tool
Artificial Intelligence (AI) Algorithms46 Analyzes neuroimaging data and cognitive test results, enhancing diagnostic accuracy and early detection
RMMJ Rambam Maimonides Medical Journal Rambam Health Care Campus 2025; 16(1): e0003. ISSN: 2076-9172
Published online 2025 January 30. doi: 10.5041/RMMJ.10539